Inducible nitric oxide synthase‐derived nitric oxide reduces vagal satiety signalling in obese mice

Inducible Nitric Oxide Synthase-Deficient Mice

An Inducible Nitric Oxide

Nitric oxide signalling in insects.

The gas, nitric oxide (NO), was first described as a second messenger molecule at least a decade ago; since then, research into mechanisms of intracellular generation of NO and of the functional role of the NO signalling pathway has generated thousands of research papers, many reviews and a Nobel Prize. This reflects the fundamental importance of NO and its signalling processes in biology and m...

Requirement of Inducible Nitric Oxide

Impaired liver regeneration in inducible nitric oxide synthasedeficient mice.

The mechanisms that permit adult tissues to regenerate when injured are not well understood. Initiation of liver regeneration requires the injury-related cytokines, tumor necrosis factor (TNF) alpha and interleukin (IL) 6, and involves the activation of cytokine-regulated transcription factors such as NF-kappabeta and STAT3. During regeneration, TNFalpha and IL-6 promote hepatocyte viability, a...